Cannabidiol (CBD)

Cannabidiol (CBD) upfu Base Ruzivo

zita	Cannabidiol （CBD）
Kuonekwa	Yakachena kujekesa yero kristaro poda
CAS	13956-29-1
Assay	≥99% (HPLC)
Solubility	Inonyungudika mumafuta, yakanyungudika zvakanyanya muEthanol uye methanol, isina kunyungudika mumvura
Molecular Weight	314.46
Melt Point	62-63 ° C
Molecular Formula	C21H30O2
mabviro	Maindasitiri hemp
Storage Temp	Tembiricha yemukamuri, ramba wakaoma uye kure nechiedza
giredha	Pharmaceutical Grade

 

Chii Cannabidiol (CBD)?

Cannabidiol inozivikanwa seCBDD iyo imwe yemakemikari anodarika zana anozivikanwa se cannabinoids inowanikwa mu cannabis kana mbanje chirimwa, Cannabis sativa. Iyo yakasarudzika uye yakanatswa kubva kumakwenzi eCannabis sativa, inongova ine zvidiki zvidiki zveTC. Tetrahydrocannabinol (THC) uye cannabidiol (CBD) ese ari maviri anowirirana neannabinoid receptors mumuviri wese.Ichienzaniswa ne100-THC, CBD haina kunyorera sezvo isingaratidzi chiitiko che psychoactive. Iine analgesic, anti-inflammatory, antineoplastic uye chemopreventive zviitiko. Pamusoro pehutungamiriri, cannabidiol (CBD) ine anti-proliferative, anti-angiogenic uye pro-apoptotic chiitiko kuburikidza nenzira dzakasiyana siyana, dzinogona kunge dzisingabatanidze kusaina ne cannabinoid receptor 9 (CB1), CB1, kana vanilloid receptor 2. reticulum (ER) kushushikana uye inhibits AKT / mTOR kusaina, nokudaro kumisikidza autophagy nekusimudzira apoptosis. Uye zvakare, CBD inowedzera chizvarwa chemarudzi eoksijeni anoshanda (ROS), ayo anowedzera kuwedzera apoptosis. Mumiriri uyu anokwidziridza kutaura kweiyo intercellular adhesion molecule 1 (ICAM-1) uye tishu inhibitor yematrix metalloproteinases-1 (TIMP1) uye inoderedza kutaura kwehibitor yeDNA inosunga 1 (ID-1). Izvi zvinotadzisa cancer cancer invasiveness uye metastasis. CBD inogona zvakare kumisikidza iyo yekupedzisira receptor inogona vanilloid mhando 1 (TRPV2), iyo inogona kuwedzera kutora kweakasiyana ma cytotoxic vamiririri mumasero ekenza. Iyo analgesic mhedzisiro yeCDD inopindirana kuburikidza nekusunga kweuyu mumiriri uye nekumisikidza kweBB2. Cannabidiol inowanzo shandiswa pakubata chirwere (pfari) kana dravet syndrome uye kusununguka kwechiratidzo kwekuenzanisira kusvika pakurwadziwa kwakanyanya kweuropathi kana zvimwe zvinorwadza mamiriro, sekenza. Iyo FDA yakabvumidza CBD muna 1, uye ndiyo chete FDA yakatenderwa kurapwa kwevarwere vane Lennox-Gastaut syndrome uye Dravet syndrome.

 

Cigore (CBD) Mitiro weAtambo

Iyo chaiyo mashandiro ekuita kweCDD uye THC haisati yanyatsonzwisiswa parizvino. Nekudaro, zvinozivikanwa kuti CBD inoshanda pane cannabinoid (CB) zvinogamuchirwa zveiyo endocannabinoid system, inowanikwa munzvimbo dzakawanda dzomuviri, kusanganisira nharaunda uye epakati masisitimu etsinga, kusanganisira huropi. Iyo endocannabinoid system inogadzirisa akawanda ehupenyu mhinduro dzemuviri kusanganisira kurwadziwa, ndangariro, chishuwo, uye mweya. Kunyanya zvakanyanya, maCB1 receptors anogona kuwanikwa mukati memarwadzo enzira dzeuropi uye musana wesipinha kwaanogona kukanganisa CBD-inosimudzira analgesia uye anxiolysis, uye CB2 zvinogamuchira zvine simba kumasero emunodzivirira, kwaanogona kukanganisa CBD-inosimudzira anti-kupisa maitiro . Cannabidiol (CBD) is metabolism inowanikwa muchiropa uye ura. Kusvuta bioavailability ingangoita 31%. Hafu yeupenyu hweCBD mushure meoromucosal spray iri pakati pe1.4 ne10.9 maawa, 2 ne5 mazuva mushure mekushandisa kwenguva refu kwemuromo, uye maawa makumi matatu nemasere mushure mekuputa. CBD ichawana kuwanda kweplasma pakati pe31 ne0 hrs. CBD yakaratidzirwa kuita seyakaipa allosteric modulator yeiyo cannabinoid CB4 receptor, iyo yakawanda kwazvo G-Protein Yakabatanidzwa Receptor (GPCR) mumuviri. Mutemo weAllosteric weanogamuchira unowanikwa kuburikidza nekushandurwa kwezviitiko zveanogamuchira pane saiti inoshanda zvakasiyana kubva kugonist kana anopikisa anosunga saiti. Izvo zvakashata allosteric modulatory mhedzisiro yeCDD ndezvekurapa kwakakosha sezvo maagonist akananga akaganhurirwa nemhedzisiro yavo ye psychomimetic nepo vapikisi vakananga vachiganhurirwa nemhedzisiro yavo inoshungurudza.

 

Mashandisiro Aungaita Cigore (CBD)?

Cannabidiol (CBD) chibodzwa checannabis icho chinoitirwa izvo zvinogona kubatsira muhutano. Idzi nzira mbiri dzinozivikanwa dzekuenda nadzo pamusika ndedzemuromo uye dzemusoro, semakapisi, zvinwiwa, mafuta ekuzora, nezvimwe.CBD mairi ndiyo inonyanya kufarirwa maitiro ekushandisa, ndiyo nzira inoshanda yekutora iyo cannabinoid. Kumedza madonhwe akati wandei eObd mafuta anoshanda senzira iri nyore uye yakadzvanywa yekushandisa mamorekuru mune iyi fashoni. Cannabidiol iri POSSIBLY SAFE painotorwa nemuromo kana kumwayiwa pasi perurimi zvakakodzera. Cannabidiol mumadhora anosvika ku 300 mg mazuva ese akatorwa nemuromo zvakachengeteka kwemwedzi mitanhatu. Doses yepamusoro ye6-1200 mg zuva nezuva yakatorwa nemuromo zvakachengeteka kwemavhiki mana. Chiremba cannabidiol chigadzirwa (Epidiolex) inobvumidzwa kutorwa nemuromo mumadosi anosvika 1500 mg / kg zuva nezuva. Cannabidiol mapiritsi anoshandiswa pasi perurimi ave achishandiswa muzvikamu zve 4 mg kwemasvondo maviri. Mumwe anogona zvakare kuwedzera CBD mafuta kuchikafu nekumwa kuti ufukidze kuravira. Asi kune avo vari kutsvaga kubatsira nemabvi akasviba kana musana wakasimba, kirimu inogona kusarudzwa.

 

Cannabidiol (CBDBatsirwa

Cannabidiol (CBD ipfupi) chinhu chinowanzoitika cannabinoid yakabva mumuti wecannabis. Icho chimwe cheanopfuura zana zana cannabinoids dzinoonekwa mumiti yehemp. Nekudaro, kusiyana nemuchero wakazara wecannabis, CBD haina THC inova inokonzeresa nematombo / kunzwa kwepamusoro kunopihwa nemushonga wekuvaraidza. Yakabviswa kubva pamaruva nemabukira eiyo hemp chirimwa, CBD iri kumanikidzwa kuita mafuta uye iri kuramba ichizivikanwa kurapa, uye kunyange kudzivirira, huwandu hwakawanda hwenyaya dzehutano mumatunhu uko mbanje yekurapa ikozvino yakanyoreswa zviri pamutemo. CBD mafuta akasimba uye akasikwa kupfuura akawanda asiri-steroidal anti-anogumbura zvinodhaka (NSAIDs). Zvese zvinhu zvinogona kuburitswa uye kukwidziridzwa kuti zvishandiswe kuburikidza nepfupi nzira distillation. Vashandisi vanogona kuwana anotevera mabhenefiti ehutano:

* Kurara uye Kunetseka

* Neurodegenerative Dambudziko

Dzora kubatwa

Hutano hwepfungwa & Kushushikana kwakanangana neMood

* Kurara Kwemhando

* Pain Management

* Bone Hutano

* Kupindwa muropa & Kuvimba

* Kunonoka kukura kwechirwere cheAlzheimer

* Inobata hutachiona hutachiona

* .Rubatsiro runopa zororo kune vanhu vane multiple sclerosis

 

Cannabidiol (CBD) Mhedzisiro

Iyo mhedzisiro mhedzisiro mhedzisiro yeCannabidiol (CBD) inosanganisira kukotsira, nyaya dzemudumbu, muromo wakaoma, kuderera kwekudya, kusvotwa, uye kudyidzana nemimwe mishonga.

Cannabidiol (CBDChikumbiro

Cannabidiol inonyanya kushandiswa pakubata chirwere (pfari), Cannabinoid inogadziriswa ne cytochrome P450 enzyme system uye inhibit zvinonyanya ma enzymes CYP3A4 uye CYP2D6. THC uye CBD zvakawanikwa zvichitadzisa CYP1A1, 1A2 uye 1B1 enzymes panguva ye in vitro zvidzidzo. Mukuwedzera CBD ine simba inhibitor yeCYP2C1P uye CYP3A4. Sezvo yakawanda yemakiriniki ekuedzwa ari kuenderera, CBD inoratidza inoshamisa mikana yekuve yekuwedzera yekurapa mune akasiyana mitezo mamiriro. Yakawanikwa iine antioxidative, anti-kupisa, uye neuroprotective mhedzisiro. Yakaratidza kuvimbisa mukurapa kwehutano hwepfungwa senge kushushikana, kurwadziwa kusingaperi, trigeminal neuralgia, chirwere cheCrohn, chirwere cheParkinson pamwe nezvinetso zvepfungwa.

Cannabidiol pfupiso

Cannabidiol inowanika mumuromo cannabinoid iyo inoshandiswa kurapa varwere vane refractory pfari nekuda kweLennox-Gastaut kana Dravet syndrome. Cannabidiol inosanganisirwa neakawanda serum enzyme kukwidziridzwa panguva yekurapa kunyanya nemadhora epamusoro asi haina kubatana nezviitiko zvekurapa zvinoita sekukuvara kwechiropa nejaundice

 

Reference

1 Britch SC, Babalonis S, Walsh SL Cannabidiol: pharmacology uye ekurapa zvinangwa. Psychopharmacology (Berl). 2021 Ndira; 238 (1): 9-28. doi: 10.1007 / s00213-020-05712-8. PMID: 33221931.

2. Samanta D. Cannabidiol: Kuongorora kweKiriniki Efficacy uye Kuchengeteka muChirwere. Pediatr Neurol. 2019 Jul; 96: 24-29. doi: 10.1016 / j.pediatrneurol. PMID: 31053391.

3. Huestis MA, Solimini R, Pichini S, Pacifici R, Carlier J, Busardò FP.Cannabidiol Migumisiro Yakashata uye Uturu. Curr Neuropharmacol. 2019; 17 (10): 974-989. doi: 10.2174 / 1570159X17666190603171901.PMID: 31161980.

4. Pisanti S, Malfitano AM nezvimwe Cannabidiol: Nyika yeunyanzvi uye matambudziko matsva ekurapa kwekushandisa. Pharmacol Ther. 2017 Jul; 175: 133-150. doi: 10.1016 / j.pharmthera.PMID: 28232276.

5. Burstein S. Cannabidiol (CBD) uye zvakafanana nazvo: ongororo yemhedzisiro yavo pane kuzvimba. Bioorg Med Chem. 2015 Kubvumbi 1; 23 (7): 1377-85. doi: 10.1016 / j.bmc.2015.01.059. PMID: 25703248.

 

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