Tadalafil

CMOAPI ine yakazara yakazara zvigadzirwa zveTadalafil, uye ine yakazara mhando yehutariri system.Also yakapfuura GMP uye DMF chitupa.

Achiratidza zvose 3 zvawanikwa

Chii chinonzi Tadalafil

Tadalafil imishonga inorayirwa inoshandiswa pakurapa erectile dysfunction (ED) uye zviratidzo zvekuwedzera kweprostate muvarume. Iyo inoratidzwa zvakare kurapa pulmonary arterial hypertension (PAH).
Tadalafil (CAS Nhamba: 171596-29-5) inowanikwa muchimiro chehwendefa yemuromo kana tadalafil poda uye inonyanya kutengeswa pasi pezita rekuti Cialis (ye erectile dysfunction kana benign prostate kuwedzera) kana Adcirca (ye pulmonary arterial hypertension). Tadalafil inowanikwawo mune yayo generic fomu iyo inogona kunge isina masimba ese sekuumbwa kwepakutanga


Tadalafil inoshanda sei?

Tadalafil imwe yeiyo phosphodiesterase mhando 5 (PDE5) inhibitors. Kana aya mapoka emishonga achitadzisa PDE5 iwozve anosimudzira erectile basa.
Munguva yekumutsa pabonde, kumiswa kunoitika kana paine kukwana kweropa kuyerera muiyo penile arteri iyo inoguma yakasununguka tsinga uye inotsvedzerera mhasuru yeiyo corpus cavernosum. Iyi mhinduro inoongororwa nekugadzirwa kwe nitric oxide (NO) mumasero endothelial uye kumagumo emitsipa. Kuburitswa kwe NO kunosimudzira iyo synthesis ye cyclic guanosine monophosphate (inonyanya kuzivikanwa se cyclic GMP kana cGMP) mumaseru akatsetseka maseru. Iyo cyclic GMP inobatsira kudzikamisa iyo yakatetepa tsandanyama uye inowedzera kuyerera kweropa kune iyo corpus cavernosum.
Tadalafil inhibits phosphodiesterase mhando 5 (PDE5) nekuwedzera huwandu hwecGMP. Izvo zvakakosha kuti uzive kuti munhu anofanirwa kuona kukurudzira kwepabonde kuti atange iyo yakasikwa kuburitswa kwe nitric oxide. Izvi zvinodaro nekuti Tadalafil mhedzisiro haizoitika pasina kukurudzira kwepabonde.
Tadalafil inogona kudzikisa zviratidzo zvekuwedzera kweprostate glands kusanganisira nekukurumidza / kugara uchiita weti, kunetsekana nekupemha, uye kusagadzikana kweweti. Inoita izvi nekuzorodza mhasuru dziri muprostate uye dundira.
Mune pulmonary hypertension, tadalafil inobatsira kusunungura tsinga dzeropa mubhokisi. Izvi zvinobatsira kuwedzera kupihwa kweropa mumapapu uye zvakare kunoderedza kuwanda kwebasa kwemoyo.


Vanopindirana veTadalafil

Mukuita kwekugadzira tadalafil (CAS 151596-29-5), vamwe vamiririri vanogadzirwa. Mamwe makambani anoshandisa tadalafil yepakati kuburitsa tadalafil.

Cas 171596-29-5

Tadalafil (CAS 171596-29-5) mushonga une simba uye unoshanda wekurapa kusagadzikana uye kuwanda kweprostatic mune varume pamwe neanopa pulmonary arteri hypertension.

Cas 171489-59-1

Cas 171489-59-1 inonziwo Chloropretadalafil iri wepakati mukugadzirwa kweTadalafil inoshandiswa pakurapa kusagadzikana kwe erectile. CAS 171489-59-1 ine molecular fomula C22H19ClN2O5 ine mamorekuru kurema kwe426.85 g / mol. Inowanikwa muchimiro chechena yakasimba.

Cas 171752-68-4

CAS 171752-68-4 ine mamorekuru fomula iri C20H18N2O4.HCl uye molekyuli uremu hwe386.83 g / mol zvakare iri tadalafil yepakati.
Kune vazhinji vatengesi ve tadalafil vepakati vanopa tadalafil yepakati yekutengesa pamakwikwi mitengo. Nekudaro, iwe paunofunga tadalafil zvitenge kubva kumakambani anovimbwa kuona kuti mhando haina kuiswa.
CMOAPI ndeimwe yetadalafil yepakati vatengesi vanovimbisa mhando yakanaka uye yemakwikwi mitengo yezvigadzirwa zvavo.


Ndiani uye sei kushandisa tadalafil

Tadalafil powder inogona kubata zvinotevera muvarume?

Erectile dysfunction

Erectile dysfunction (ED) inonziwo kusasimba imamiriro mune varume umo ivo vasingakwanise kuwana kana kuchengeta erection kwenguva yakakwana yekuita bonde. Izvo zvinowanzo kutungamira mukufarira bonde uye zvinogona zvakare kukonzera kumwe kushushikana senge nguva isati yakwana kana kunonoka kumisikidzwa uye dzimwe nguva kutadza kusvika pachirume.
ED inogona kukonzerwa nezvikonzero zvakawanda zvese zvepanyama uye zvepamoyo mamiriro akadai sezvimwe zvirwere zvakaita seshuga, chirwere chemwoyo, uye neBP, zera, kushushikana, kana kunyangwe nyaya dzehukama.
Tadalafil inobatsira kubata ED nekuwedzera kuyerera kweropa kuenda kunhengo. Izvi zvinobatsira kuzadzisa uye chengeta erection. Nekudaro, tadalafil inobatsira chete nekumisikidza kana munhu atove nekukurudzirwa pabonde.

Benign prostatic hyperplasia (BPH)

Iyo inonziwo kuwedzera kweprostate gland kuwedzera, BPH inowanzoitika mamiriro anowanikwa mune varume pakukwegura kwavo. Nekudaro, zvimwe zvinhu zvinoverengeka zvinogona kutungamira kukuwedzera kweprostate inosanganisira chirwere cheshuga uye kusagadzikana kwemoyo, mararamiro, uye kunyanya kufutisa pamwe nenhoroondo yemhuri yeBPH. Kana prostate ichiwedzera inogona kutungamira kune weti mamiriro.
Zviratidzo zvinosanganisirwa neyakawedzera prostate gland ndeiyi, inokurumidza uye inowanzo kukurudzira kukurudzira, kunetseka kutanga kuita weti, isina simba weti rukova, kana kutadza kuburitsa dundira zvizere. Zvimwe zviratidzo zveBPH zvinogona kusanganisira Urinary turakiti hutachiona (UTI), isingakwanise kuita weti, kana ropa murini.
Tadalafil poda kana piritsi inobatsira kusunungura mhasuru muprostate uye bladder. Izvi zvinobatsira kubvisa zviratidzo zveBPH.

Pulmonary arteri hypertension (PAH)

PAH mamiriro ezvinhu umo mune kukwirira kweropa mumitsinga inopa ropa kumapapu. Izvo zvakasiyana neyakajairika yakakwira BP. Zvinoitika kana tsinga dzinobva pamoyo kusvika kumapapu dzikamanikana kana kuvharika.
Zviratidzo zvinonyanya kuzivikanwa zvinosanganisira kurwadziwa pachipfuva, kurukutika, kana kuzvimba makumbo ako nemakumbo.
Tadalafil inogona kubatsira kubvisa zviratidzo zvePAH nekuzorodza tsinga dzeropa mumapapu zvinoteedzana zvinowedzera kuyerera kweropa.

Nzira yekushandisa tadalafil?

Iyo tadalafil dosage inoenderana nezera rako, yakashandiswa kushandiswa, uye chero imwe nyaya yezvokurapa.
Kushandiswa kweTadalafil hakukurudzirwe kuvana vari pasi pemakore gumi nemasere uye zvakare vane makore anopfuura makumi matanhatu nemashanu vanofanirwa kungwarira sezvo miviri yavo inotora nguva yakareba kutora mishonga iyi.
Pane mirayiridzo yakajeka yekuti ungashandisa sei tadalafil powder asi fomu yakajairika ndeye tadalafil piritsi pasi pemazita emhando dzakasiyana.
Zvinokurudzirwa kutora tadalafil kamwe zuva nezuva uye kuitora panguva yakafanana zuva rega rega kuti uwane tadalafil mabhenefiti.
Iyo tadalafil muyero wekushandisa kwakasiyana unotsanangurwa;
Zvekusagadzikana kwe erectile, muyero we2.5-5 mg unotorwa zuva nezuva kana 10 mg kana uchinge watorwa kamwechete sekuda kwese.
Kune benign prostatic hyperplasia, muyero we5 mg inotorwa zuva nezuva inokurudzirwa. Tadalafil inofanira kutorwa kamwe zuva nezuva.
Kana uchibata nemamiriro ese ari maviri (erectile kudzvinyirira uye yakawedzera prostate) muyero we5 mg pazuva wakakodzera.
Iine pulmonary arterial hypertension, iyo tadalafil dosage ye40 mg inotorwa zuva nezuva inokurudzirwa.
Kungofanana nemamwe madhiragi, chinoshanda kune mumwe chingasaite zvakafanana kune chimwe. Tadalafil dzimwe nzira dziripo. Nekudaro, chinhu chakanakisa kuita kutaura nachiremba wako nezvenzira dziripo tadalafil uye uone kuti ndezvipi zvakakukodzera. Iwe unogona kurairwa kutora tadalafil dzimwe nzira kana uri weergoria kune tadalafil kana nekuda kwezvimwe zvikonzero.
Ndiro basa rako kucherechedza izvo zvinoshanda zvakanaka kwauri iwe paunenge uchitonga kuti tadalafil ndiyo sarudzo kana iyo tadalafil mhedzisiro inobvisa iyo tadalafil mabhenefiti.


Ndechipi musiyano pakati peTadalafil nemimwe mishonga yekusagadzikana kwe erectile

Cialis (Tadalafil)

Cialis imishonga inonyorwa mukirasi yemishonga inonzi Phosphodiesterase-5 Enzyme Inhibitors. Iyo inoshandiswa kurapa zviratidzo zvekusagadzikana kwe erectile. Inogona kushandiswa yoga kana kurongedzwa pamwe chete nemamwe madhiragi.

Dapoxetine Hydrochloride

Dapoxetine hydrochloride inorondedzerwa seinokurumidza-kuita inosarudza serotonin reuptake inhibitors (SSRIs).
Dapoxetine hydrochloride imishonga yakanyoreswa inoshandiswa kurapa ejaculation isati yakwana. Kukurumidza kumera ejaculation chiitiko chinowanzoitika muvarume icho chinosanganisira kutadza kunonoka kubuda. Ichi ndicho chimwe chiratidzo chekusagadzikana kwe erectile mumarume.
Kunyangwe zvese zviri zviviri tadalafil uye dapoxetine hydrochloride zvinoshandiswa kurapa zviratidzo zvekusagadzikana kweiyo erectile, imwe tadalafil ndeye phosphodiesterase inhibitor nepo imwe, dapoxetine, iri kusarudza serotonin reuptake inhibitor.

Vardenafil Hydrochloride

Vardenafil mushonga uri muboka remishonga inonzi phosphodiesterase (PDE) inhibitors. Inoshandiswa kurapa murume erectile kudzvinyirira. Kana murume akamutswa pabonde, vardenafil inowedzera kuyerera kweropa kuenda panhengo yemurume izvo zvinoita kuti uve nechokwadi chekuwana erection.
Vardenafil inotengeswa pasi pezita rekuti Levitra inosarudzika kupfuura sildenafil uye tadalafil (Cialis) kuenda PDE5. Izvi zvinongoreva kuti muyero wezasi wevardenafil unodiwa uine mashoma mhedzisiro.
Mumwe mutsauko unozivikanwa uri muhafu yeupenyu apo vardenafil (Levitra) ine hafu yeupenyu hwemaawa 4-6 kusvika tadalafil (Cialis) ine hafu yeupenyu hwemaawa 17.5. Izvi zvinoreva kuti Tadalafil (Cialis) inoshanda kwenguva yakareba kupfuura vardenafil.

Avanafil

Avanafil imishonga muboka re phosphodiesterase inhibitors. Iyo inoshandiswa zvakare kurapa kusagadzikana kwe erectile nekuvandudza kuyerera kweropa mudunhu repenile.
Kunyangwe zvese zviri zviviri avanafil uye tadalafil iri phosphodiesterase inhibitors, avanafil ndiyo nyowani uye iine hupfupi hafu-hupenyu hwemaawa mashanu pane tadalafil iyo ine hafu yeupenyu kwemaawa 5.
Mukupedzisa, tadalafil yakanyanya kunaka nekuda kweiyo yakareba hafu yeupenyu. Mumwe anogona kutora mushonga wit mashoma anokwanisika mhedzisiro.


Tadalafil Side mhedzisiro uye mabhenefiti

Tadalafil inobatsira

Vazhinji vanofunga kushandisa tadalafil powder vanozvitenga nekuda kweiyo huru tadalafil mabhenefiti;

Kurapa kusagadzikana kwe erectile

Penile erection inzira yakakosha yekuita bonde. Erectile kudzvinyirira kunoitika kana murume atadza kuwana nekuchengetedza erection. Izvi zvinokonzeresa nyaya zhinji senge kushushikana, kushomeka, uye kunyangwe hukama hwehukama.
Erection inowanikwa kana paine kukwana kwakakwana kweropa kuyerera munhengo yemurume. Tadalafil inobatsira kubvisa zviratidzo zvekusagadzikana kwe erectile nekuwedzera kuyerera kweropa kuenda kunhengo.

Kurapa zviratidzo zvebenign prostatic hyperplasia

Benign prostatic hyperplasia inonziwo yakawedzera prostate gland. Ichi chiitiko chinoitika zvakasikwa nezera. Kana iyo gland yeprostate ikawedzera, inosvina urethra. Zvimwe zvezviratidzo zvine chekuita neprostate yakawedzerwa ndeaya; kukurumidza uye kugara uchiita weti, zvakaoma kutanga kuita weti, zvinorwadza kuita weti pakati pevamwe.
Tadalafil inobatsira varume vanotambura nebenign prostatic hyperplasia nekusunungura izvi zviratidzo. Tadalafil powder inobatsira kuzorodza iyo gland yeprostate pamwe neya dundira nekudaro inoderedza zviratidzo zvine chekuita neyakaomeswa dundira uye urethra.

Inogona kurapa ese erectile kusagadzikana uye benign prostatic hyperplasia

Tadalafil inogona zvakare kubatsira varume vanotambura neese erectile kudzvinyirira uye yakawedzera prostate gland panguva imwe chete.
Paunoshandisa tadalafil muyero chaiyo uye sezvakakurudzirwa iwe unokohwa izvo zvataurwa. Sezvo ini ndichiwedzera kuyerera kweropa mudunhu repenile uye zvakare mune dzimwe nzvimbo, inzira ine hutano yekutarisana nemamiriro aya.

Inogona zvakare kushandiswa pakurapa zviratidzo zveplmonary arterial hypertension

Pulmonary arterial hypertension (PAH) zvinoreva kuti kune kukwirisa kweropa mutsinga dzinotora ropa kubva mumoyo kuenda kumapapu. Izvo zvakadaro zvakasiyana neyakajairika BP.
PAH inoitika apo tsinga dzinopa ropa mumapapu dzinova nhete kana dzakavharika zvichitungamira moyo kumanikidzwa kupomba ropa pamwero wakakwira. Uku kumhanyisa uye kumanikidza kurova kwemoyo kunoguma nekumanikidza kwakanyanya mutsinga.
Tadalafil powder inoshamisika nekuzorodza tsinga dzeropa. Iko kuzorora kunotendera kuyerera kwakatsetseka kweropa nekudaro kunowedzera mwero wekuyerera. Izvi zvinobatsira moyo kupomba ropa kutsetseka nekudaro rinobvisa kumanikidza kwaizoungana neimwe nzira

Inovandudza kugona kwako kurovedza muviri

Munguva yekurovedza muviri kuyerera kweropa kwakakosha kubvumira munhu kuwana oxygen yakakwana pamwe nekugadzira simba rakaringana rinodiwa.
Tadalafil inogona kusimudzira yako yekuekisesaiza kuita nekuzorodza tsinga dzako dzeropa uye nekuwedzera kuyerera kweropa.

Tadalafil mhedzisiro

Iyo yakajairika tadalafil mhedzisiro inosanganisira;

  • Kutemwa nemusoro,
  • Nausea,
  • kuburitsa (kudziya, kutsvuka, kana kunzwa kunetseka),
  • dumbu rakatsamwa,
  • yakakora kana inomhanya mhino, uye
  • kurwadziwa kwemhasuru, kurwadziwa musana, uye kurwadziwa mumaoko ako kana makumbo.

Tadalafil inogona zvakare kutungamira kune mamwe akakomba mhedzisiro. Iwe unorayirwa kutsvaga rubatsiro rwechiremba kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge waita tadalafil mhedzisiro

  • kumwe kurwara kwemoyo zviratidzo zvinosanganisira kurwadziwa pachipfuva, kurwadziwa kuchipararira kushaya kana pabendekete, kuda kurutsa, uye kudikitira.
  • chiratidzo chinoshanduka kusanganisira kusaona zvakanaka kana kurasikirwa kamwe kwemaonero.
  • kuburitsa (kudziya, kutsvuka, kana kunzwa kunetseka),
  • Kunzwa kukanganisika mukati
  • kurira munzeve dzako uye kurasikirwa kwekunzwa
  • Erection inorwadza kana inogara kwenguva yakareba kupfuura maawa mana sezvo izvi zvinogona kukuvadza nhengo yako.
  • Kudzora
  • Kusagadzikana kwepfungwa
  • Kufenda, dzungu uye,
  • Kuneta zvisina kujairika.

Kupindirana kwezvinodhaka zveTadalafil

Kuwanda kwekubatana kwetadalafil nemimwe mishonga kwakataurwa. Kubatana kwezvinodhaka kazhinji kunochinja mashandiro emishonga uye kunogona kutadzisa mishonga kushanda nemazvo.
Saka zvinokurudzirwa zvikuru kuti utaure nezvemishonga yako usati washandisa tadalafil. Kumwe kudyidzana kwetadalafil kunogona kuve kwakapfava uye kwakashata.
Pazasi pane kutaurirana kwetadalafil;

Nitrates

Ivo vanonziwo seAnguina madhiragi. Kana maitrate atorwa pamwe chete netadalafil, zvinogona kukonzeresa kumanikidza kweropa kudonha kusvika kumazinga akaderera kwazvo. Iyo yakaderera mwero weBP inosanganiswa nezviratidzo senge dzungu kana kutofenda.
Mimwe yematambudziko ekurwadziwa anosanganisira; butyl nitrite, amyl nitrite, isosorbide dinitrate, nitroglycerin, uye isosorbide mononitrate.

Alpha-blockers

Iyi ndiyo mishonga inoshandiswa kugadzirisa kukwirira kweropa. Izvo zvinoshandiswawo mukurapa kweprostate. Ose maviri tadalafil uye alpha-blockers ndeavasodilator vane kuwedzerwa kweropa kuderera nemhedzisiro. Kana ikashandiswa pamwechete, inogona kukonzeresa kudonha / kwakakosha kudonha kweropa. Izvi zvinoita kuti munhu ave nedzungu uye anogona zvakare kupera simba.
Mimwe yealpha-blockers zvinodhaka zvinosanganisira; terazosin, tamsulosin, alfuzosin, uye prazosin.

Mimwe mishonga yeHIV

Iyi mishonga ndeyeprotease inhibitors uye nekudaro inogona kuwedzera iyo tadalafil muropa. Uku kuwedzera kunoguma nekuderera kweropa. Izvo zvinogona zvakare kukonzera kukoshesa mune varume zvinoreva kuti vanowana yakawedzera erection iyo inowanzo kurwadza.
Mimwe yemishonga iyi ndeye ritonavir uye lopinavir.

Antibiotics

Kupindirana kweTadalafil nemishonga inorwisa mabhakitiriya kwakataurwa. Kana ikatorwa pamwe chete netadalafil, mishonga inorwisa mabhakitiriya inogona kuwedzera mwero we tadalafil muropa iyo inotungamira kudzikisa BP. Yake inogona kukonzeresa dzungu, kufenda, uye kunyangwe mamwe maonero ekuona. Izvo zvinogona zvakare kukonzera kukoshesa mune varume.
Mimwe yemishonga iyi ndeye erythromycin, telithromycin, uye clarithromycin.
Nekudaro, mamwe maantibayoti anogona kudzikisa iwo mazinga e tadalafil muropa. Idzi tadalafil kudyidzana kunoita kuti isashande nemazvo. Iyi mishonga inosanganisira; rifampin.

Antifungal zvinodhaka

Mimwe yemuromo antifungal zvinodhaka zvinosanganisira ketoconazole uye itraconazole inosangana ne tadalafil.
Iyi mishonga inogona kusimudza mwero we tadalafil inotungamira kune dzungu uye kupera simba kunogona kuitika.

Mimwe pulmonary hypertension zvinodhaka

Tadalafil uye mamwe mapurmoni hypertension zvinodhaka zvinozivikanwa kuva neropa-kumanikidza-kudzikisa mhedzisiro. Kana ikashandiswa pamwe chete inogona kutungamira kune zvine ngozi zvakaderera huwandu hweropa. Izvi zvinoguma yakaderera BP-inosangana nezviratidzo senge dzungu nekufenda.
Mishonga iyi inosanganisira riociguat.

Maantacids

Iyi mishonga inoshandiswa kubvisa dumbu acid. Kana ikashandiswa pamwe chete ne tadalafil, inogona kutadzisa kunwa kwe tadalafil mumuviri. Zvinosanganisira magnesium hydroxide kana aluminium hydroxide.

Epilepsy mishonga

Aya anonziwo ma anti-seizure drug. Paunotora anti-seizure zvinodhaka pamwe chete ne tadalafil, zvinogona kudzikisa kutora kwetadalafil. Izvi zvinoreva kuti tadalafil haizokwanisa kushanda nemazvo. Iyi pfari zvinodhaka zvinosanganisira phenytoin, phenobarbital, uye carbamazepine.


Ndekupi kwekutenga Tadalafil?

Iwe unogona kugadzira Tadalafil kutenga pazvitoro zvepamhepo. Iyo poda inowanikwa yakawanda kune vaongorori nevanoongorora. Ive neshuwa yekutarisa tadalafil powder inogamuchirwa vatengesi Paunofunga kutora tadalafil iritenge kubva kune vakavimbika vatengesi.
Bvunza chiremba wako usati watora tadalafil nekuda kwekukanganisa tadalafil mhedzisiro pamwe nekubatana kwe tadalafil nemimwe mishonga.
Kana iwe uchitsvaga Tadalafil kana ayo epakati, iwe unofanirwa kutarisa neCMOAPI kuti uwane unovhenekerwa kupihwa kwakachena zvigadzirwa. Makomputa edu akawana vimbiso yemhando yepamusoro.


References
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